Four people who spent three days off Earth in September 2021 experienced physical and mental changes that included modest declines in cognitive tests, stressed immune systems and genetic changes within their cells, scientists report in a package of papers published on Tuesday in the journal Nature and several other related journals.
Almost all of what changed in the astronauts returned to normal after they splashed down on Earth. None of the alterations appeared to pose a showstopping caution for future space travelers. But the results also highlighted how little medical researchers know.
Christopher Mason, a professor of genomics, physiology and biophysics at Weill Cornell Medicine in New York City and one of the leaders of the research, called the collection of papers and data “the most in-depth examination we’ve ever had of a crew” as he spoke during a news conference on Monday.
The four people selected to represent a “wider swath of society” include billionaire Jared Isaacman, who led the mission; Hayley Arceneaux, a physician assistant; Sian Proctor, a community college professor; and Christopher Sembroski, an engineer. However, researchers anonymized each person’s data from the Inspiration4 mission.